Identification of galectin-7 as a potential biomarker for esophageal squamous cell carcinoma by proteomic analysis.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies. Early diagnosis is critical for guiding the therapeutic management of ESCC. It is imperative to find more effective biomarkers of ESCC.

Methods

To identify novel biomarkers for esophageal squamous cell carcinoma (ESCC), specimens from 10 patients with ESCC were subjected to a comparative proteomic analysis. The proteomic patterns of ESCC samples and normal esophageal epithelial tissues (NEETs) were compared using two-dimensional gel electrophoresis. And differentially expressed proteins were identified using MALDI-TOF-MS/MS. For further identification of protein in selected spot, western blotting and immunohistochemistry were employed.

Results

Twelve proteins were up-regulated

SUBMITTER: Zhu X 

PROVIDER: S-EPMC3087317 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature