Hippocampal size anomalies in a community-based cohort with childhood-onset epilepsy.

ABSTRACT:

Objectives

Epidemiologic evidence suggests the natural history of refractory mesial temporal lobe epilepsy is complicated, yet little is known about the hippocampus from the nontertiary center perspective.

Methods

In a community-based cohort, individuals with nonsyndromic focal epilepsy with onset <16 years and controls had research MRI scans. Hippocampal (HC) volumes were manually measured, corrected for total brain volume, and converted to Z scores (Z(HC)) based on the controls' values. Volumes in cases and controls were compared.

Results

Average volumes were not significantly different in cases with unknown cause (n = 117) relative to controls (n = 63). The group with structural and other conditions (n = 23) had significantly smaller volumes. Asymmetry (larger/smal

SUBMITTER: Berg AT 

PROVIDER: S-EPMC3087401 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature