Cerebral blood flow by arterial spin labeling in poststroke dementia.

ABSTRACT:

Objective

To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD).

Methods

This cohort study used arterial spin labeling MRI at 3 T to examine cerebral blood flow (CBF). We scanned 39 patients 6 years after stroke. They were older than 75 years at the time of stroke and free of dementia 3 months poststroke, with 8 subsequently developing dementia. We also scanned 17 subjects with AD and 29 healthy control subjects. We determined the perfusion in regions of interest (ROIs). Hippocampal volume was also measured using a previously validated automated procedure.

Results

The gray matter/white matter CBF ratio was reduced globally in the poststroke dementia (PSD) group (1.55 SD = 0.12) relat

SUBMITTER: Firbank MJ 

PROVIDER: S-EPMC3087466 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature