Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38.

ABSTRACT:

Background

The purpose of this study was to investigate the effect of TAS2R38 haplotypes and age on human bitter taste perception.

Results

Children (3 to 10 yrs), adolescents (11 to 19 yrs) and adults (mostly mothers, 20 to 55 yrs (N = 980) were measured for bitter taste thresholds for 6-n-propylthiouracil (PROP) and genotyped for three polymorphisms of the AS2R38 gene (A49P, V262A, I296V). Subjects were grouped by haplotype and age, as well as sex and race/ethnicity, and compared for PROP thresholds. Subjects with the same haplotype were similar in bitter threshold regardless of race/ethnicity (all ages) or sex (children and adolescents; all p-values > 0.05) but age was a modifier of the genotype-phenotype relationship. Specifically, AVI/PAV heterozygous children could perc

SUBMITTER: Mennella JA 

PROVIDER: S-EPMC3087510 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature