Haplotypes of the porcine peroxisome proliferator-activated receptor delta gene are associated with backfat thickness.

ABSTRACT:

Background

Peroxisome proliferator-activated receptor delta belongs to the nuclear receptor superfamily of ligand-inducible transcription factors. It is a key regulator of lipid metabolism. The peroxisome proliferator-activated receptor delta gene (PPARD) has been assigned to a region on porcine chromosome 7, which harbours a quantitative trait locus for backfat. Thus, PPARD is considered a functional and positional candidate gene for backfat thickness. The purpose of this study was to test this candidate gene hypothesis in a cross of breeds that were highly divergent in lipid deposition characteristics.

Results

Screening for genetic variation in porcine PPARD revealed only silent mutations. Nevertheless, significant associations between PPARD haplotypes and backfat thicknes

SUBMITTER: Meidtner K 

PROVIDER: S-EPMC3087513 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature