Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells.

ABSTRACT:

Background

While the diversity and spatio-temporal origin of olfactory bulb (OB) GABAergic interneurons has been studied in detail, much less is known about the subtypes of glutamatergic OB interneurons.

Results

We studied the temporal generation and diversity of Neurog2-positive precursor progeny using an inducible genetic fate mapping approach. We show that all subtypes of glutamatergic neurons derive from Neurog2 positive progenitors during development of the OB. Projection neurons, that is, mitral and tufted cells, are produced at early embryonic stages, while a heterogeneous population of glutamatergic juxtaglomerular neurons are generated at later embryonic as well as at perinatal stages. While most juxtaglomerular neurons express the T-Box protein Tbr2, those generate

SUBMITTER: Winpenny E 

PROVIDER: S-EPMC3087671 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature