Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine.

ABSTRACT:

Background

The rapid progress currently being made in genomic science has created interest in potential clinical applications; however, formal translational research has been limited thus far. Studies of population genetics have demonstrated substantial variation in allele frequencies and haplotype structure at loci of medical relevance and the genetic background of patient cohorts may often be complex.

Methods and findings

To describe the heterogeneity in an unselected clinical sample we used the Affymetrix 6.0 gene array chip to genotype self-identified European Americans (N = 326), African Americans (N = 324) and Hispanics (N = 327) from the medical practice of Mount Sinai Medical Center in Manhattan, NY. Additional data from US minority groups and Brazil were used for ex

SUBMITTER: Tayo BO 

PROVIDER: S-EPMC3087725 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature