No association of xenotropic murine leukemia virus-related viruses with prostate cancer.

ABSTRACT:

Background

The association of the xenotropic murine leukemia virus-related virus (XMRV) with prostate cancer continues to receive heightened attention as studies report discrepant XMRV prevalences ranging from zero up to 23%. It is unclear if differences in the diagnostic testing, disease severity, geography, or other factors account for the discordant results. We report here the prevalence of XMRV in a population with well-defined prostate cancers and RNase L polymorphism. We used broadly reactive PCR and Western blot (WB) assays to detect infection with XMRV and related murine leukemia viruses (MLV).

Methodology/principal findings

We studied specimens from 162 US patients diagnosed with prostate cancer with a intermediate to advanced stage (Gleason Scores of 5-10; moderate

SUBMITTER: Switzer WM 

PROVIDER: S-EPMC3087753 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature