Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways.

ABSTRACT:

Background

Elevated levels of acute phase proteins (APP) are often found in patients with cardiovascular diseases. In a previous study, we demonstrated the importance of the IL-6-gp130 axis -as a key regulator of inflammatory acute phase signaling in hepatocytes-for the development of atherosclerosis.

Background/principal findings

Gp130-dependent gene expression was analyzed in a previously established hepatocyte-specific gp130 knockout mouse model. We performed whole transcriptome analysis in isolated hepatocytes to measure tissue specific responses after proinflammatory stimulus with IL-6 across different time points. Our analyses revealed an unexpected small gene cluster that requires IL-6 stimulus for early activation. Several of the genes in this cluster are involved in

SUBMITTER: Luchtefeld M 

PROVIDER: S-EPMC3087798 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature