PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress.

ABSTRACT: We have previously cloned and characterized a novel p53 and DNA damage-regulated gene named PDRG1. PDRG1 was found to be differentially regulated by ultraviolet (UV) radiation and p53. In this study, we further investigated stress regulation of PDRG1 and found it to be selectively regulated by agents that induce genotoxic stress (DNA damage). Using cancer profiling arrays, we also investigated PDRG1 expression in matching normal and tumor samples representing various malignancies and found its expression to be upregulated in multiple malignancies including cancers of the colon, rectum, ovary, lung, stomach, breast and uterus when compared to their respective matched normal tissues. Western blot and immunohistochemical analyses were also performed on select specimen sets of colon cancers an

SUBMITTER: Jiang L 

PROVIDER: S-EPMC3087961 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature