EyeSite: a semi-automated database of protein families in the eye.

ABSTRACT: The EyeSite is a web-based database of protein families for proteins that function in the eye and their homologous sequences. The resource clusters proteins at different levels of homology in order to facilitate functional annotation of sequences and modelling of proteins from structural homologues. Eye proteins are organized into the tissue types in which they function and are clustered into homologous families using a novel protocol employing the TribeMCL algorithm. Homologous families are further subdivided into sequence clusters for which multiple sequence alignments are generated. Structural annotations from the CATH domain database are provided for nearly 90% of the sequences, and protein family annotations from the Pfam database for approximately 86%. Homology models have also been

SUBMITTER: Lee DA 

PROVIDER: S-EPMC308824 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature