Genetics of warfarin sensitivity in an emergency department population with thromboembolic.

ABSTRACT:

Background

Emergency department (ED) patients with venous thromboembolism (VTE) are eventually treated with a standard dose of warfarin despite the fact that a number of patients are known to be sensitive to warfarin and may experience supra-therapeutic INRs and adverse bleeding events. Pharmacogenetics is an emerging field of medical practice that seeks to improve drug safety and efficacy in an individual patient by tailoring treatment to the patient's known genetic makeup.

Objective

To identify patients with risk for warfarin sensitivity among an ED population with VTE and to assess if the warfarin sensitivity mutations were of significant enough prevalence to be of clinical significance in customizing treatment of VTE. We sought in a pilot study to identify if testing for

SUBMITTER: Johnson SW 

PROVIDER: S-EPMC3088368 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature