TopoSNP: a topographic database of non-synonymous single nucleotide polymorphisms with and without known disease association.

ABSTRACT: The database of topographic mapping of Single Nucleotide Polymorphism (topoSNP) provides an online resource for analyzing non-synonymous SNPs (nsSNPs) that can be mapped onto known 3D structures of proteins. These include disease- associated nsSNPs derived from the Online Mendelian Inheritance in Man (OMIM) database and other nsSNPs derived from dbSNP, a resource at the National Center for Biotechnology Information that catalogs SNPs. TopoSNP further classifies each nsSNP site into three categories based on their geometric location: those located in a surface pocket or an interior void of the protein, those on a convex region or a shallow depressed region, and those that are completely buried in the interior of the protein structure. These unique geometric descriptions provide more detaile

SUBMITTER: Stitziel NO 

PROVIDER: S-EPMC308838 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature