Temporal control of contractile ring assembly by Plo1 regulation of myosin II recruitment by Mid1/anillin.

ABSTRACT: In eukaryotes, cytokinesis generally involves an actomyosin ring, the contraction of which promotes daughter cell segregation. Assembly of the contractile ring is tightly controlled in space and time. In the fission yeast, contractile ring components are first organized by the anillin-like protein Mid1 into medial cortical nodes. These nodes then coalesce laterally into a functional contractile ring. Although Mid1 is present at the medial cortex throughout G2, recruitment of contractile ring components to nodes starts only at mitotic onset, indicating that this event is cell-cycle regulated. Polo kinases are key temporal coordinators of mitosis and cytokinesis, and the Polo-like kinase Plo1 is known to activate Mid1 nuclear export at mitotic onset, coupling division plane specification to

SUBMITTER: Almonacid M 

PROVIDER: S-EPMC3088474 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature