Near-infrared imaging method for the in vivo assessment of the biodistribution of nanoporous silicon particles.

ABSTRACT: In the development of new nanoparticle-based technologies for therapeutic and diagnostic purposes, understanding the fate of nanoparticles in the body is crucial. We recently developed a multistage vector delivery system comprising biodegradable and biocompatible nanoporous silicon particles (first-stage microparticles [S1MPs]) able to host, protect, and deliver second-stage therapeutic and diagnostic nanoparticles (S2NPs) on intravenous injection. This delivery system aims at sequentially overcoming the biologic barriers en route to the target delivery site by separating and assigning tasks to the coordinated logic-embedded vectors constituting it. In this work, by conjugating a near-infrared dye on the surface of the S1MP without compromising the porous structure and potential loading of

SUBMITTER: Tasciotti E 

PROVIDER: S-EPMC3088648 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature