Varied pathways of stage IA lung adenocarcinomas discovered by integrated gene expression analysis.

ABSTRACT:

Background

Discovery of the progression-associated genes and pathways in lung adenocarcinoma (LAD) has important implications in understanding the molecular mechanism of tumor development. However, few studies had been performed to focus on the changes of pathways in lung adenocarcinoma development using microarray expression profile.

Result

We performed a meta-analysis of 4 LAD microarray datasets encompassing 353 patients to reveal differentially expressed genes (DEGs) between normal lung tissues and LAD of different stages. Overall, 1 838 genes were found to be dys-regulated, and the adipogenesis, circadian rhythm, and Id pathways were significantly changed. Interestingly, most of the genes from the same gene family (such as Interleukin receptor, Matrix metallopeptidase,

SUBMITTER: Chen C 

PROVIDER: S-EPMC3088877 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature