Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm.

ABSTRACT: In the female reproductive tract, mammalian sperm undergo a regulated sequence of prefusion changes that "prime" sperm for fertilization. Among the least understood of these complex processes are the molecular mechanisms that underlie sperm guidance by environmental chemical cues. A "hard-wired" Ca(2+) signaling strategy that orchestrates specific motility patterns according to given functional requirements is an emerging concept for regulation of sperm swimming behavior. The molecular players involved, the spatiotemporal characteristics of such motility-associated Ca(2+) dynamics, and the relation between a distinct Ca(2+) signaling pattern and a behavioral sperm phenotype, however, remain largely unclear. Here, we report the functional characterization of two human sperm chemoreceptors.

SUBMITTER: Veitinger T 

PROVIDER: S-EPMC3089573 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature