The role of the fat mass and obesity associated gene (FTO) in breast cancer risk.

ABSTRACT:

Background

Obesity has been shown to increase breast cancer risk. FTO is a novel gene which has been identified through genome wide association studies (GWAS) to be related to obesity. Our objective was to evaluate tissue expression of FTO in breast and the role of FTO SNPs in predicting breast cancer risk.

Methods

We performed a case-control study of 354 breast cancer cases and 364 controls. This study was conducted at Northwestern University. We examined the role of single nucleotide polymorphisms (SNPs) of intron 1 of FTO in breast cancer risk. We genotyped cases and controls for four SNPs: rs7206790, rs8047395, rs9939609 and rs1477196. We also evaluated tissue expression of FTO in normal and malignant breast tissue.

Results

We found that all SNPs were significantl

SUBMITTER: Kaklamani V 

PROVIDER: S-EPMC3089782 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature