Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.

ABSTRACT:

Objective

The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associated with MBL deficiency and increased susceptibility to sepsis. We postulate that the variant MBL-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ARDS).

Design

Nested case-control study.

Setting

Tertiary academic medical center.

Patients

Two hundred and twelve Caucasians with ARDS and 442 controls genotyped for the variant X, D, B, and C alleles of codon -221, 52, 54, and 57, respectively.

Interventions

None.

Measurements and main results

Patients homozygous for the variant codon 54B allele (54BB) had worse severity of illness on admission (p = .007), greater likelihood of septic shock (p = .

SUBMITTER: Gong MN 

PROVIDER: S-EPMC3090269 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature