ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses.

ABSTRACT:

Objective

The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)] and lipid profile in Greek young nurses.

Methods

The study population consisted of 308 unrelated nurses who were genotyped and the ABCA1 polymorphisms were detected. Additionally, lipid profile [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] was evaluated.

Results

There was no difference in the genotypic and allelic frequencies of the R219K polymorphism according to lipid profile. The R1587K genotypes di

SUBMITTER: Kolovou V 

PROVIDER: S-EPMC3090361 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature