Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo.

ABSTRACT:

Background

Medulloblastoma is the most common brain tumor in children, and its prognosis is worse than for many other common pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effects. Thus, it is imperative to identify safer, effective treatments for medulloblastoma. In this study we evaluated the anti-cancer potential of curcumin in medulloblastoma by testing its ability to induce apoptosis and inhibit tumor growth in vitro and in vivo using established medulloblastoma models.

Methods

Using cultured medulloblastoma cells, tumor xenografts, and the Smo/Smo transgenic medulloblastoma mouse model, the antitumor effects of curcumin were tested in vitro and in vivo.

Results

Curcumin induced apoptosis and cell cycle arrest at the G2

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC3090367 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature