The level of protein in milk formula modifies ileal sensitivity to LPS later in life in a piglet model.

ABSTRACT:

Background

Milk formulas have higher protein contents than human milk. This high protein level could modify the development of intestinal microbiota, epithelial barrier and immune functions and have long-term consequences.

Methodology/principal findings

We investigated the effect of a high protein formula on ileal microbiota and physiology during the neonatal period and later in life. Piglets were fed from 2 to 28 days of age either a normoprotein (NP, equivalent to sow milk) or a high protein formula (HP, +40% protein). Then, they received the same solid diet until 160 days. During the formula feeding period ileal microbiota implantation was accelerated in HP piglets with greater concentrations of ileal bacteria at d7 in HP than NP piglets. Epithelial barrier function was a

SUBMITTER: Chatelais L 

PROVIDER: S-EPMC3090415 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature