Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility.

ABSTRACT:

Background

Germline polymorphisms can influence gene expression networks in normal mammalian tissues and can affect disease susceptibility. We and others have shown that analysis of this genetic architecture can identify single genes and whole pathways that influence complex traits, including inflammation and cancer susceptibility. Whether germline variants affect gene expression in tumors that have undergone somatic alterations, and the extent to which these variants influence tumor progression, is unknown.

Results

Using an integrated linkage and genomic analysis of a mouse model of skin cancer that produces both benign tumors and malignant carcinomas, we document major changes in germline control of gene expression during skin tumor development resulting from cell selectio

SUBMITTER: Quigley DA 

PROVIDER: S-EPMC3091303 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature