Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.

ABSTRACT:

Background

Millions of humans and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which exclusively infect keratinized host structures. To provide broad insights into the molecular basis of the pathogenicity-associated traits, we report the first genome sequences of two closely phylogenetically related dermatophytes, Arthroderma benhamiae and Trichophyton verrucosum, both of which induce highly inflammatory infections in humans.

Results

97% of the 22.5 megabase genome sequences of A. benhamiae and T. verrucosum are unambiguously alignable and collinear. To unravel dermatophyte-specific virulence-associated traits, we compared sets of potentially pathogenicity-associated proteins, such as secreted protea

SUBMITTER: Burmester A 

PROVIDER: S-EPMC3091305 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature