High resolution discovery and confirmation of copy number variants in 90 Yoruba Nigerians.

ABSTRACT:

Background

Copy number variants (CNVs) account for a large proportion of genetic variation in the genome. The initial discoveries of long (> 100 kb) CNVs in normal healthy individuals were made on BAC arrays and low resolution oligonucleotide arrays. Subsequent studies that used higher resolution microarrays and SNP genotyping arrays detected the presence of large numbers of CNVs that are < 100 kb, with median lengths of approximately 10 kb. More recently, whole genome sequencing of individuals has revealed an abundance of shorter CNVs with lengths < 1 kb.

Results

We used custom high density oligonucleotide arrays in whole-genome scans at approximately 200-bp resolution, and followed up with a localized CNV typing array at resolutions as close as 10 bp, to confirm regions fr

SUBMITTER: Matsuzaki H 

PROVIDER: S-EPMC3091319 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature