Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline.

ABSTRACT: The C. elegans germline provides an excellent model for analyzing the regulation of stem cell activity and the decision to differentiate and undergo meiotic development. The distal end of the adult hermaphrodite germline contains the proliferative zone, which includes a population of mitotically cycling cells and cells in meiotic S phase, followed by entry into meiotic prophase. The proliferative fate is specified by somatic distal tip cell (DTC) niche-germline GLP-1 Notch signaling through repression of the redundant GLD-1 and GLD-2 pathways that promote entry into meiosis. Here, we describe characteristics of the proliferative zone, including cell cycle kinetics and population dynamics, as well as the role of specific cell cycle factors in both cell cycle progression and the decision bet

SUBMITTER: Fox PM 

PROVIDER: S-EPMC3091494 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature