Emotion processing, major depression, and functional genetic variation of neuropeptide Y.

ABSTRACT:

Context

Despite recent progress in describing the common neural circuitry of emotion and stress processing, the bases of individual variation are less well understood. Genetic variants that underlie psychiatric disease have proven particularly difficult to elucidate. Functional genetic variation of neuropeptide Y (NPY) was recently identified as a source of individual differences in emotion. Low NPY levels have been reported in major depressive disorder (MDD).

Objective

To determine whether low-expression NPY genotypes are associated with negative emotional processing at 3 levels of analysis.

Design

Cross-sectional, case-control study.

Setting

Academic medical center.

Participants

Among 44 individuals with MDD and 137 healthy controls, 152 (84%) had an N

SUBMITTER: Mickey BJ 

PROVIDER: S-EPMC3091621 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature