Sequencing, annotation, and comparative genome analysis of the gerbil-adapted Helicobacter pylori strain B8.

ABSTRACT:

Background

The Mongolian gerbils are a good model to mimic the Helicobacter pylori-associated pathogenesis of the human stomach. In the current study the gerbil-adapted strain B8 was completely sequenced, annotated and compared to previous genomes, including the 73 supercontigs of the parental strain B128.

Results

The complete genome of H. pylori B8 was manually curated gene by gene, to assign as much function as possible. It consists of a circular chromosome of 1,673,997 bp and of a small plasmid of 6,032 bp carrying nine putative genes. The chromosome contains 1,711 coding sequences, 293 of which are strain-specific, coding mainly for hypothetical proteins, and a large plasticity zone containing a putative type-IV-secretion system and coding sequences with unknown function

SUBMITTER: Farnbacher M 

PROVIDER: S-EPMC3091624 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature