Response of the mosquito protein interaction network to dengue infection.

ABSTRACT:

Background

Two fifths of the world's population is at risk from dengue. The absence of effective drugs and vaccines leaves vector control as the primary intervention tool. Understanding dengue virus (DENV) host interactions is essential for the development of novel control strategies. The availability of genome sequences for both human and mosquito host greatly facilitates genome-wide studies of DENV-host interactions.

Results

We developed the first draft of the mosquito protein interaction network using a computational approach. The weighted network includes 4,214 Aedes aegypti proteins with 10,209 interactions, among which 3,500 proteins are connected into an interconnected scale-free network. We demonstrated the application of this network for the further annotation of mo

SUBMITTER: Guo X 

PROVIDER: S-EPMC3091628 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature