Comparative genome analysis of a large Dutch Legionella pneumophila strain collection identifies five markers highly correlated with clinical strains.

ABSTRACT:

Background

Discrimination between clinical and environmental strains within many bacterial species is currently underexplored. Genomic analyses have clearly shown the enormous variability in genome composition between different strains of a bacterial species. In this study we have used Legionella pneumophila, the causative agent of Legionnaire's disease, to search for genomic markers related to pathogenicity. During a large surveillance study in The Netherlands well-characterized patient-derived strains and environmental strains were collected. We have used a mixed-genome microarray to perform comparative-genome analysis of 257 strains from this collection.

Results

Microarray analysis indicated that 480 DNA markers (out of in total 3360 markers) showed clear variation in pre

SUBMITTER: Yzerman E 

PROVIDER: S-EPMC3091632 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature