The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes.

ABSTRACT:

Background

The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells. The chemokine system is complex in that multiple chemokines can bind to one chemokine receptor and vice versa. Although chemokine receptors have been well characterised in humans, the chemokine receptor repertoire of cattle is not well characterised and many sequences are yet to be experimentally validated.

Results

We have identified and sequenced bovine homologs to all identified functional human chemokine receptors. The bovine chemokine receptors show high levels of similarity to their human counterparts and similar genome arrangements. We have also characterised an additional bovine chemokine receptor, not present in the

SUBMITTER: Widdison S 

PROVIDER: S-EPMC3091636 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature