Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler.

ABSTRACT:

Background

The rate of emergence of human pathogens is steadily increasing; most of these novel agents originate in wildlife. Bats, remarkably, are the natural reservoirs of many of the most pathogenic viruses in humans. There are two bat genome projects currently underway, a circumstance that promises to speed the discovery host factors important in the coevolution of bats with their viruses. These genomes, however, are not yet assembled and one of them will provide only low coverage, making the inference of most genes of immunological interest error-prone. Many more wildlife genome projects are underway and intend to provide only shallow coverage.

Results

We have developed a statistical method for the assembly of gene families from partial genomes. The method takes full ad

SUBMITTER: Kepler TB 

PROVIDER: S-EPMC3091641 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature