Replication-biased genome organisation in the crenarchaeon Sulfolobus.

ABSTRACT:

Background

Species of the crenarchaeon Sulfolobus harbour three replication origins in their single circular chromosome that are synchronously initiated during replication.

Results

We demonstrate that global gene expression in two Sulfolobus species is highly biased, such that early replicating genome regions are more highly expressed at all three origins. The bias by far exceeds what would be anticipated by gene dosage effects alone. In addition, early replicating regions are denser in archaeal core genes (enriched in essential functions), display lower intergenic distances, and are devoid of mobile genetic elements.

Conclusion

The strong replication-biased structuring of the Sulfolobus chromosome implies that the multiple replication origins serve purposes other tha

SUBMITTER: Andersson AF 

PROVIDER: S-EPMC3091651 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature