Positional differences in the wound transcriptome of skin and oral mucosa.

ABSTRACT:

Background

When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. Recent studies suggest that intrinsic differences in inflammation, growth factor production, levels of stem cells, and cellular proliferation capacity may underlie the exceptional healing that occurs in oral mucosa. The current study was designed to compare the transcriptomes of oral mucosal and skin wounds in order to identify critical differences in the healing response at these two sites using an unbiased approach.

Results

Using microarray analysis, we explored the differences in gene expression in skin and oral mucosal wound healing in a murine model of paired equivalent sized wounds. Samples were examined from days 0 to 10 and spanned all stages of the wound healing proce

SUBMITTER: Chen L 

PROVIDER: S-EPMC3091667 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature