A potential role for intragenic miRNAs on their hosts' interactome.

ABSTRACT:

Background

miRNAs are small, non-coding RNA molecules that mainly act as negative regulators of target gene messages. Due to their regulatory functions, they have lately been implicated in several diseases, including malignancies. Roughly half of known miRNA genes are located within previously annotated protein-coding regions ("intragenic miRNAs"). Although a role of intragenic miRNAs as negative feedback regulators has been speculated, to the best of our knowledge there have been no conclusive large-scale studies investigating the relationship between intragenic miRNAs and host genes and their pathways.

Results

miRNA-containing host genes were three times longer, contained more introns and had longer 5' introns compared to a randomly sampled gene cohort. These results are c

SUBMITTER: Hinske LC 

PROVIDER: S-EPMC3091682 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature