Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling.

ABSTRACT:

Background

There was a large scale outbreak of the highly pathogenic porcine reproductive and respiratory syndrome (PRRS) in China and Vietnam during 2006 and 2007 that resulted in unusually high morbidity and mortality among pigs of all ages. The mechanisms underlying the molecular pathogenesis of the highly virulent PRRS virus (H-PRRSV) remains unknown. Therefore, the relationship between pulmonary gene expression profiles after H-PRRSV infection and infection pathology were analyzed in this study using high-throughput deep sequencing and histopathology.

Results

H-PRRSV infection resulted in severe lung pathology. The results indicate that aberrant host innate immune responses to H-PRRSV and induction of an anti-apoptotic state could be responsible for the aggressive repli

SUBMITTER: Xiao S 

PROVIDER: S-EPMC3091693 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature