Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion.

ABSTRACT:

Background

Zinc deficiency is detrimental to organisms, highlighting its role as an essential micronutrient contributing to numerous biological processes. To investigate the underlying molecular events invoked by zinc depletion we performed a temporal analysis of transcriptome changes observed within the zebrafish gill. This tissue represents a model system for studying ion absorption across polarised epithelial cells as it provides a major pathway for fish to acquire zinc directly from water whilst sharing a conserved zinc transporting system with mammals.

Results

Zebrafish were treated with either zinc-depleted (water = 2.61 μg L-1; diet = 26 mg kg-1) or zinc-adequate (water = 16.3 μg L-1; diet = 233 mg kg-1) conditions for two weeks. Gill samples were collected at five ti

SUBMITTER: Zheng D 

PROVIDER: S-EPMC3091697 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature