Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence.

ABSTRACT:

Background

Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C. Stadtman in 1954, it has been generally regarded as a "gold mine" for novel biochemical reactions and is used as a model organism for studying metabolic aspects such as the Stickland reaction, coenzyme-B12- and selenium-dependent reactions of amino acids. With the goal of revisiting its carbon, nitrogen, and energy metabolism, and comparing studies with other clostridia, its genome has been sequenced and analyzed.

Results

C. sticklandii is one of the best biochemically studied proteolytic clostridial species. Useful additional information has been obtained from the sequencing and annotation of its genome, wh

SUBMITTER: Fonknechten N 

PROVIDER: S-EPMC3091704 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature