Response of swine spleen to Streptococcus suis infection revealed by transcription analysis.

ABSTRACT:

Background

Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health. Systematical information about host immune response to the infection is important for understanding the molecular mechanism of diseases.

Results

104 and 129 unique genes were significantly up-regulated and down-regulated in the spleens of pigs infected with SS2 (WT). The up-regulated genes were principally related to immune response, such as genes involved in inflammatory response; acute-phase/immune response; cell adhesion and response to stress. The down-regulated genes were mainly involved in transcription, transport, material and energy metabolism which were representative of the reduced vital activity of SS2-influenced cells

SUBMITTER: Li R 

PROVIDER: S-EPMC3091705 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature