Genome-wide expression patterns in physiological cardiac hypertrophy.

ABSTRACT:

Background

Genome-wide expression patterns in physiological cardiac hypertrophy. Co-expression patterns in physiological cardiac hypertrophy

Results

In this study, the first large-scale analysis of publicly available genome-wide expression data of several in vivo murine models of physiological LVH was carried out using network analysis. On evaluating 3 million gene co-expression patterns across 141 relevant microarray experiments, it was found that physiological adaptation is an evolutionarily conserved processes involving preservation of the function of cytochrome c oxidase, induction of autophagy compatible with cell survival, and coordinated regulation of angiogenesis.

Conclusion

This analysis not only identifies known biological pathways involved in physiological

SUBMITTER: Drozdov I 

PROVIDER: S-EPMC3091706 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature