Transcriptomic and functional analysis of the Anopheles gambiae salivary gland in relation to blood feeding.

ABSTRACT:

Background

The Anopheles gambiae salivary glands play a major role in malaria transmission and express a variety of bioactive components that facilitate blood-feeding by preventing platelet aggregation, blood clotting, vasodilatation, and inflammatory and other reactions at the probing site on the vertebrate host.

Results

We have performed a global transcriptome analysis of the A. gambiae salivary gland response to blood-feeding, to identify candidate genes that are involved in hematophagy. A total of 4,978 genes were found to be transcribed in this tissue. A comparison of salivary gland transcriptomes prior to and after blood-feeding identified 52 and 41 transcripts that were significantly up-regulated and down-regulated, respectively. Ten genes were further selected to ass

SUBMITTER: Das S 

PROVIDER: S-EPMC3091715 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature