Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in Plasmodium falciparum.

ABSTRACT:

Background

Elevated parasite biomass in the human red blood cells can lead to increased malaria morbidity. The genes and mechanisms regulating growth and development of Plasmodium falciparum through its erythrocytic cycle are not well understood. We previously showed that strains HB3 and Dd2 diverge in their proliferation rates, and here use quantitative trait loci mapping in 34 progeny from a cross between these parent clones along with integrative bioinformatics to identify genetic loci and candidate genes that control divergences in cell cycle duration.

Results

Genetic mapping of cell cycle duration revealed a four-locus genetic model, including a major genetic effect on chromosome 12, which accounts for 75% of the inherited phenotype variation. These QTL span 165 genes,

SUBMITTER: Reilly Ayala HB 

PROVIDER: S-EPMC3091725 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature