A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins.

ABSTRACT:

Background

Peroxide turnover and signalling are involved in many biological phenomena relevant to human diseases. Yet, all the players and mechanisms involved in peroxide perception are not known. Elucidating very remote evolutionary relationships between proteins is an approach that allows the discovery of novel protein functions. Here, we start with three human proteins, SRPX, SRPX2 and CCDC80, involved in tumor suppression and progression, which possess a conserved region of similarity. Structure and function prediction allowed the definition of P-DUDES, a phylogenetically widespread, possibly ancient protein structural domain, common to vertebrates and many bacterial species.

Results

We show, using bioinformatics approaches, that the P-DUDES domain, surprisingly, adopts

SUBMITTER: Pawlowski K 

PROVIDER: S-EPMC3091736 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature