Copy number variation in the porcine genome inferred from a 60 k SNP BeadChip.

ABSTRACT:

Background

Recent studies in pigs have detected copy number variants (CNVs) using the Comparative Genomic Hybridization technique in arrays designed to cover specific porcine chromosomes. The goal of this study was to identify CNV regions (CNVRs) in swine species based on whole genome SNP genotyping chips.

Results

We used predictions from three different programs (cnvPartition, PennCNV and GADA) to analyze data from the Porcine SNP60 BeadChip. A total of 49 CNVRs were identified in 55 animals from an Iberian x Landrace cross (IBMAP) according to three criteria: detected in at least two animals, contained three or more consecutive SNPs and recalled by at least two programs. Mendelian inheritance of CNVRs was confirmed in animals belonging to several generations of the IBMAP c

SUBMITTER: Ramayo-Caldas Y 

PROVIDER: S-EPMC3091738 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature