Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse.

ABSTRACT:

Background

Sexual dimorphism in brain gene expression has been recognized in several animal species. However, the relevant regulatory mechanisms remain poorly understood. To investigate whether sex-biased gene expression in mammalian brain is globally regulated or locally regulated in diverse brain structures, and to study the genomic organisation of brain-expressed sex-biased genes, we performed a large scale gene expression analysis of distinct brain regions in adult male and female mice.

Results

This study revealed spatial specificity in sex-biased transcription in the mouse brain, and identified 173 sex-biased genes in the striatum; 19 in the neocortex; 12 in the hippocampus and 31 in the eye. Genes located on sex chromosomes were consistently over-represented in all bra

SUBMITTER: Reinius B 

PROVIDER: S-EPMC3091755 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature