Structure and dynamics of the operon map of Buchnera aphidicola sp. strain APS.

ABSTRACT:

Background

Gene expression regulation is still poorly documented in bacteria with highly reduced genomes. Understanding the evolution and mechanisms underlying the regulation of gene transcription in Buchnera aphidicola, the primary endosymbiont of aphids, is expected both to enhance our understanding of this nutritionally based association and to provide an intriguing case-study of the evolution of gene expression regulation in a reduced bacterial genome.

Results

A Bayesian predictor was defined to infer the B. aphidicola transcription units, which were further validated using transcriptomic data and RT-PCR experiments. The characteristics of B. aphidicola predicted transcription units (TUs) were analyzed in order to evaluate the impact of operon map organization on the reg

SUBMITTER: Brinza L 

PROVIDER: S-EPMC3091783 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature