Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes.

ABSTRACT:

Background

Adherent and invasive Escherichia coli (AIEC) are commonly found in ileal lesions of Crohn's Disease (CD) patients, where they adhere to intestinal epithelial cells and invade into and survive in epithelial cells and macrophages, thereby gaining access to a typically restricted host niche. Colonization leads to strong inflammatory responses in the gut suggesting that AIEC could play a role in CD immunopathology. Despite extensive investigation, the genetic determinants accounting for the AIEC phenotype remain poorly defined. To address this, we present the complete genome sequence of an AIEC, revealing the genetic blueprint for this disease-associated E. coli pathotype.

Results

We sequenced the complete genome of E. coli NRG857c (O83:H1), a clinical isolate of AIE

SUBMITTER: Nash JH 

PROVIDER: S-EPMC3091784 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature