A genomic perspective on the potential of Actinobacillus succinogenes for industrial succinate production.

ABSTRACT:

Background

Succinate is produced petrochemically from maleic anhydride to satisfy a small specialty chemical market. If succinate could be produced fermentatively at a price competitive with that of maleic anhydride, though, it could replace maleic anhydride as the precursor of many bulk chemicals, transforming a multi-billion dollar petrochemical market into one based on renewable resources. Actinobacillus succinogenes naturally converts sugars and CO2 into high concentrations of succinic acid as part of a mixed-acid fermentation. Efforts are ongoing to maximize carbon flux to succinate to achieve an industrial process.

Results

Described here is the 2.3 Mb A. succinogenes genome sequence with emphasis on A. succinogenes's potential for genetic engineering, its metabolic att

SUBMITTER: McKinlay JB 

PROVIDER: S-EPMC3091790 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature