The role of multifunctional M1 metallopeptidases in cell cycle progression.

ABSTRACT:

Background

Metallopeptidases of the M1 family are found in all phyla (except viruses) and are important in the cell cycle and normal growth and development. M1s often have spatiotemporal expression patterns which allow for strict regulation of activity. Mutations in the genes encoding M1s result in disease and are often lethal. This family of zinc metallopeptidases all share the catalytic region containing a signature amino acid exopeptidase (GXMXN) and a zinc binding (HEXXH[18X]E) motif. In addition, M1 aminopeptidases often also contain additional membrane association and/or protein interaction motifs. These protein interaction domains may function independently of M1 enzymatic activity and can contribute to multifunctionality of the proteins.

Scope

A brief review of M1 me

SUBMITTER: Peer WA 

PROVIDER: S-EPMC3091800 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature