Fibronectin is an important regulator of flow-induced vascular remodeling.

ABSTRACT:

Objective

Fibronectin is an important regulator of cell migration, differentiation, growth, and survival. Our data show that fibronectin also plays an important role in regulating extracellular matrix (ECM) remodeling. Fibronectin circulates in the plasma and is also deposited into the ECM by a cell dependent process. To determine whether fibronectin affects vascular remodeling in vivo, we asked whether the fibronectin polymerization inhibitor, pUR4, inhibits intima-media thickening, and prevents excess ECM deposition in arteries using a mouse model of vascular remodeling.

Methods and results

To induce vascular remodeling, partial ligation of the left external and internal carotid arteries was performed in mice. pUR4 and the control peptide were applied periadventitially in

SUBMITTER: Chiang HY 

PROVIDER: S-EPMC3091823 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature